Month: July 2019

  • A piece of legislation that would mean children ar

    first_imgA piece of legislation that would mean children are taught LGBT-inclusive relationships and sex education (RSE) in primary schools was passed by a huge majority of 517 yesterday, with 538 MPs in favour and just 21 against.But LGBT Labour activists are furious about those MPs who voted against or abstained on the Draft Relationships Education, Relationships and Sex Education and Health Education (England) Regulations 2019.Relationships and sex education (RSE) has been under scrutiny in recent weeks, as several schools in Birmingham faced protests over existing guidance and some stopped teaching the disputed lessons.As might be expected, 12 Tories and 7 DUP representatives voted against the guidance. But many Labour members were concerned to see that Labour’s John Spellar also voted against, as did Fiona Onasanya, who now sits as an Independent MP.14 Labour MPs did not vote: Vernon Coaker, Sir David Crausby, Ruth George, Kate Hoey, Kate Hollern, Imran Hussain, Stephen Kinnock (who says there has been a mistake), Khalid Mahmood, John McDonnell, Laura Pidcock, Yasmin Qureshi, Stephen Timms, Keith Vaz and Mohammad Yasin.Ex-Labour MPs Ann Coffey, Frank Field, Ivan Lewis, Jared O’Mara (who has explained his absence), Chuka Umunna and Chris Williamson also abstained.Not all abstentions were deliberate, and one seems to have been a mistake. Some of the MPs offered explanations in response to criticism…Stephen Kinnock said there had been a “mix up”.I am absolutely sure that I voted ‘For’ on this. I am contacting the House authorities now to see if there has been some kind of mix up.— Stephen Kinnock (@SKinnock) March 28, 2019Laura Pidcock apologised:I can only apologise. I was on TV live, then got called to an urgent meeting, so it was a cock up from me, not a deliberate abstention. Spent years delivering LGBT+ education 😭— Laura Pidcock MP (@LauraPidcockMP) March 28, 2019Ruth George said it was a scheduling issue:This was a minor division held at the same time as my Bill to prohibit Sky Lanterns, to enable a score of Conservative MPs to register their objection, but was overwhelmingly won. No reflection on my total support for the LGBT community – I’m speaking at Buxton Pride this summer— Ruth George (@RuthGeorge6) March 28, 2019Timms explained his (deliberate) abstention in parliament.Mohammad Yasin had a family emergency:@LGBTLabourI had a family emergency. Unfortunately I missed few votes on Tuesday and Wednesday.— Mohammad Yasin MP (@yasinmpbedford) March 28, 2019 Tags:LGBT Labour /LGBT /RSE /last_img read more

  • ST HELENS have extended the contract of New Zealan

    first_imgST HELENS have extended the contract of New Zealand international forward Tony Puletua for a further two seasons until the end of 2013.Puletua is currently in his third year with the Saints.Puletua stated: “I’m absolutely thrilled to be seeing out my career at the Saints. They are the only Super League club that I would consider playing for and I’ve enjoyed every aspect of my time here so far, particularly the fans who have been absolutely amazing to me.“With the new stadium near to completion, and some new international signings to complement a great crop of young players coming through, the next couple of years are going to be more than exciting for Saints players and fans alike.”Coach Royce Simmons added: “This is a great lift for us all. Tony is a rare breed of forward who combines size with athleticism and skill and can play both back and front row.“He brings an extra dimension to our game and has been in great form of late. He is in prime physical condition and there is no doubt that he can play on at the highest level for another couple of seasons after this.”last_img read more

  • Wilmington hotel sends used soap to be recycled given to the impoverished

    first_img00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave Settings WILMINGTON, NC (WWAY) — Five-hundred pounds of soap, shampoo, conditioner and lotion. That’s how much Homewood Suites in Mayfaire says they supply their rooms with each month.Plenty of it doesn’t get used by guests and could go to waste. That waste is magnified during busy times like Spring Break.- Advertisement – “When we do have more people coming in for more of a transient stay to the beach for the weekend, we will see more people utilizing it and then it being left behind,” said Joanie DeSantis, Homewood Suites’ Director of Sales.The leftover toiletries get sent to the Clean the World program. That’s where hygiene kits are compiled and sent to impoverished people all around the world.“Two of the melted down bars of soap. Any of the lotion, shampoo, conditioner that is more than halfway full when it is sent back to Clean the World gets repurposed into these hygiene kits. They also get a towel, a razor, toothbrush, and toothpaste,” DeSantis said.Related Article: Blood pressure drug recalled over potentially life-threatening label mix-upAccording to Clean the World, about five thousand children die daily from hygiene-related illnesses.DeSantis says her hotel plays a small role in solving this big problem.“I think anything that’s gonna give back to make our world a better place is fantastic, especially if it’s helping people that are in need, children, families. There’s really no bad side to it at all,” DeSantis said.All suites associated with Hilton Hotels participate in this program.Homewood Suites at Mayfaire plans to donate 75 of the hygiene kits to the Wilmington Interfaith Hospitality Network and a local domestic violence shelter.last_img read more

  • Novant Health receives grant to support breast health services in Brunswick County

    first_img To qualify for a free mammogram, women who do not have health insurance or are underinsured must be age 40 or up, live in Brunswick County and cannot have had a mammogram in the last year.“We are grateful to the Susan G. Komen organization for helping us bridge the gap in breast cancer screening with this generous grant,” said Cindy Cheatham, development program manager for the Novant Health Brunswick Medical Center Foundation. “This means so much to us as we know it will help us bring a vital diagnostic tool to the women in our community who forgo mammograms because they cannot afford them.”The American College of Radiology recommends that all women 40 and older receive an annual mammogram.Related Article: Medical staff attend annual NHRMC trauma symposiumStandard mammograms and 3D mammograms are available at Brunswick Medical Center six days a week. The mobile mammography coach is also available at various Brunswick County locations and features standard, digital mammography technology, all female technicians, private changing and separate clinical exam room.For more information or to schedule your mammogram, call 910-721-1485 or visit NovantHealth.org/Pink. 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave Settings BOLIVIA, NC (WWAY) — Novant Health has received a big grant that will help women in Brunswick County get needed breast health services.Susan G. Komen North Carolina Triangle to the Coast donated nearly $20,000 to The Novant Health Brunswick Medical Center Foundation to provide free mammograms and diagnostic services for uninsured and underinsured women in Brunswick County.- Advertisement – last_img read more

  • Law enforcement conducting active shooter drill at Brunswick Co school

    first_imgActive shooter training at Cedar Grove Middle School on July 26, 2018. (Photo: Basil John/WWAY) BRUNSWICK COUNTY, NC (WWAY) — The Brunswick County Sheriff’s Office will conduct a multi-agency active shooter drill today with the help of Brunswick County Schools.The drill will be held on the campus of South Brunswick High School in Southport starting at 9 a.m.- Advertisement – Agencies from across the county including Emergency Services, various municipalities and fire departments, and the NC State Highway Patrol will be participating in the drill. Faculty and staff from Brunswick County Schools will also participate as role players in the scenarios.  The drill will include realistic scenarios in an effort to give participants the most real-life experience possible in an effort to prevent or minimize loss of life in the event of an active shooter.The purpose of the drill is to provide realistic training for first responders in the event of an active shooter situation inside one of the nineteen schools across the county.Residents may see an increased number of law enforcement and emergency personnel in the area as part of the drill.  Tactical exercises will take place in and around the school and is closed to the public.Related Article: Teacher says she was fired after refusing to abide by ‘no zero’ policyWWAY’s Kylie Jones will be there for the exercise and will have the story throughout the day.last_img read more

  • Former CFCC president named as Bladen Community College president

    first_img “Dr. Lee brings a vast amount of experience, not only in the classroom, but as an administrator within the community college system. She has done an outstanding job engaging the community and growing the relationships necessary to make a community college thrive. We, as a family at Bladen Community College, are excited and confident that Dr. Lee will grow the college with continued success. We welcome Dr. Lee’s leadership as we enter the next era of BCC’s history,” said Dennis Troy, chair of BCC’s Board of Trustees.In October 2017, Lee abruptly resigned as President of CFCC, the same day CFCC’s Board of Trustees announced a legal settlement with former President Ted Spring. As part of that settlement, CFCC’s insurer paid Spring an undisclosed amount of money, and he withdrew a lawsuti claiming he was forced to resign in 2015.Jim Morton was selected as Lee’s successor at CFCC.Related Article: North Carolina speaker, schools chief pitching bond questionLee had been with CFCC for more than a decade, starting as an instructor in 2003. Since living Wilmington, she has served as the Chief of Staff and Vice President of Academic Affairs at Union College in Barbourville, Kentucky, according to the news release.Dr. Lee is expected to assume the office on February 1. Dr. Amanda Lee selected as new BCC President (Photo: BCC) BLADEN COUNTY, NC (WWAY) — The former president of Cape Fear Community College will lead another eastern North Carolina school.Bladen Community College announced last week that Amanda Lee will become the school’s president after state approval. According to a news release, the school’s board of trustees unanimously selected Lee from a pool of four finalists.- Advertisement – last_img read more

  • 19 places where you can take your unwanted medications Saturday

    first_imgPills (Photo: Pixabay) WILMINGTON, NC (WWAY) — To encourage the proper disposal of unwanted medications, New Hanover Regional Medical Center is partnering with regional healthcare, law enforcement, and education and safety organizations to hold a medication disposal event in six counties Saturday.19 locations in New Hanover, Brunswick, Pender, Onslow, Bladen and Duplin counties are scheduled to accept all medications and syringes from 10 a.m. to 2 p.m.- Advertisement – Medications can be prescription, over-the-counter, vitamins or herbal. You are asked to keep medications in original containers. Syringes and other sharps will be accepted.New Hanover CountyNHRMC Medical Mall, 2243 S. 17th St., WilmingtonNHRMC ExpressCare, 510 Carolina Bay Drive, WilmingtonNHRMC Atlantic SurgiCenter, 9104 Market St., WilmingtonCarolina Beach Police Department, 1121 N. Lake Park Blvd., Carolina BeachNew Hanover County Senior Resource Center, 2222 S. College Rd., WilmingtonUNCW Police Department, 5126 Lionfish Drive, WilmingtonNew Hanover Medical Group – Myrtle Grove, 5145 S. College Road, WilmingtonMedNorth Health Center, 925 N. Fourth St., WilmingtonBrunswick CountyNHRMC Health & Diagnostics Brunswick Forest, 1333 S. Dickenson Dr., LelandNovant Health Brunswick Medical Center, 240 Hospital Dr. NE, BoliviaRelated Article: New Hampshire sets tough drinking water standards for PFASPender CountyPender Memorial Hospital, 507 E. Freemont St., BurgawIsland Family Medicine, 2540 N.C. 210 East, Surf CityVillage Pharmacy of Hampstead, Inc., 14057 US-17 #100, HampsteadBlack River Health Services, Inc., 4811 N.C. 50, Maple HillOnslow CountyOnslow Memorial Hospital, 317 Western Blvd., JacksonvilleBladen CountyAnderson Drug Store, 206 South Poplar St., ElizabethtownClarkton Drug, 80 East Green St., ClarktonMedicine Shoppe Pharmacy, 102 Main St., BladenboroDuplin CountyVidant Duplin Hospital, 401 N. Main, St., KenansvilleFor those who cannot attend the event, permanent drop boxes are available in many locations in Southeastern NC for residents to safely dispose of unwanted medications. No needles or biohazard materials are accepted in the drop boxes. To find a location, visit https://www.nhrmc.org/medication-disposallast_img read more

  • Woody White to represent county at Pearl Harbor ceremony

    first_img The USS North Carolina is a Virginia-class fast-attack nuclear submarine.Its official commissioning ceremony was held in Wilmington in May of 2008.A local non-profit youth woodworking program “Kids Making It” engraved farewell plaques for crew members when they transition.Related Article: Presumed American remains from Korea War head homeThe ceremony is in Hawaii at 10 a.m. Friday. Commander Matthew Lewis & Commissioner Woody White (Photo: Kids Making It) NEW HANOVER COUNTY, NC (WWAY) — New Hanover County Commissioner Woody White is headed to Pearl Harbor in Hawaii to represent the county and the Board of Commissioners at the Change of Command Ceremony for the USS North Carolina submarine.Commander Matthew H. Lewis will be relieved by Commander Michael D. Fisher at the ship’s home port in Pearl Harbor.- Advertisement – last_img read more

  • Two Brunswick County men arrested over the weekend in separate rapes

    first_imgSean Michael Lent and Madison Collins (Photos: Brunswick Co. Sheriff’s Office) BRUNSWICK COUNTY, NC (WWAY) — Two Brunswick County men were arrested over the weekend and charged in two separate rape investigations, one involving a young child.Sean Michael Lent, 25, is charged with rape of a child by an adult and sexual offense with a child by an adult.- Advertisement – According to warrants, the alleged crimes happened between November 2014 and November 2016 and involved a child between the ages of 3 and 4. Lent was between 20 to 22 years old at the time.Lent was arrested Sunday night and is being held under a more than $1 million bond.Madison Reeves Collins, 21, is charged with second degree forcible rape and second degree force sex offense.Related Article: South Carolina man arrested in 1987 rape in North CarolinaAccording to the arrest warrant, the incident happened on June 1.He was arrested on Friday and is being held under a $200,000 bond.last_img read more

  • PN launches manifesto for each Local Council

    first_img Luke Zerafa Luke Zerafa Luke Zerafa Luke ZerafaLuke Zerafa The Nationalist Party launched election manifestos for the 68 localities in the Local Council elections.During the news conference, Secretary General of the Nationalist Party Clyde Puli, explained that the PN was publishing an overall manifesto and specific manifestos addressing specific needs for each locality. This amounted to more than 2,000 proposals.Among the proposals are strengthening the communities, strengthening identity, environmental landscaping, night shelters and day care centers for each locality, community policing and caring for residents.The Opposition spokesperson on local councils Robert Cutajar, explained that the Nationalist Party submitted 80 proposals for local councils, most of which were rejected by the government. Luke Zerafa Luke Zerafa SharePrint Luke Zerafa Luke Zerafacenter_img WhatsApp Luke Zerafa 1 of 11 Luke Z Luke Zerafa Luke Zerafa <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=ab2c8853&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=97&amp;cb={random}&amp;n=ab2c8853&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a>last_img read more

  • Shooting at Virginia Beach municipal centre leaves 12 dead including suspect

    first_imgTwitterTwitter A disgruntled city employee opened fire at the municipal centre in Virginia Beach, Virginia, on Friday afternoon, killing 11 people and wounding at least six others before he was killed himself, the city’s police chief said.Chief James Cervera said the precise circumstances of the shooting in the coastal resort city remained under investigation. He gave few details of what was known, but said a police officer was among those who were struck by gunfire but survived.Cervera said the suspect was a longtime current municipal employee, and described him as “disgruntled.” It was not made immediately clear whether the gunman took his own life or was killed in an exchange of gunfire with police.The shooting unfolded, according to Cervera, shortly after 4 p.m. at Building Two of the municipal centre complex, a facility which houses the city’s public works and utilities next door to City Hall.Virginia Beach, which sits on the Atlantic coast at the mouth of the Chesapeake Bay, is the state’s most populous city with roughly 450,000 year-round residents.“This is the most devastating day in the history of Virginia Beach,” Mayor Bobby Dyer said at a news conference with the police chief. “The people involved are our friends, co-workers, neighbours, colleagues.”WhatsApp SharePrint <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=ab2c8853&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=97&amp;cb={random}&amp;n=ab2c8853&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a>last_img read more

  • Juventus sign promising defender from Genoa

    first_img <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=a7617b59&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=128&amp;cb={random}&amp;n=a7617b59&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a> SharePrint Juventus have made another important signing as they look to rejuvenate their ageing defence. Last season’s Serie A winners have completed the signing of Cristian Romero for €26 million from Genoa before loaning him back to the same side for a season.The Argentine joined Genoa from Belgrano last year for a reported €1.7m and managed 27 Serie A appearances during his debut season. A statement on Juventus’ website read:“Juventus announces that the agreement with Genoa for the definitive acquisition of the registration rights of the player Cristian Romero has been finalised for a consideration of €26m payable in three financial years.”WhatsApplast_img read more

  • Jack Bauers return with 24 Live Another Day to start on 5514

    first_imgStar “Jack Baeur” Advertisement This May, 24 is coming back, four years after the conclusion of its eighth and “final” season.THis was revealed during thes Super Bowl where Fox aired several teasers for the upcoming 12-episode run.The “limited television event” — which is titled Live Another Day — is a major break from 24’s traditional format. Each episode will still represent an hour in real time, but fans can expect the show to jump forward in time between episodes. – Advertisement – Kiefer Sutherland is reprising his role as the incomparable Jack Bauer, and other characters from 24’s past including Chloe O’Brien and James Heller are also set to return. See the teaser below.last_img read more

  • Seedstars Worlds 500000 startup challenge debuts in Uganda tomorrow

    first_imgAdvertisement Seedstars World (SSW) will make its debut in Uganda on the 27th of June, continuing on its journey to emerging markets and fast-growing startup scenes.Seedstars World is the most exclusive startup competition for emerging markets and fast-growing startup scenes. Based in Geneva, Switzerland and founded by Alisee de Tonnac and Pierre-Alain Masson, it is supported by the venture builder Seedstars SA.SSW2013 Semifinalist, incuding startups from Nigeria and Ghana2013’s tour of 20 cities ended with a final round in Geneva, where the most promising startups from all over the world competed one last time in front of an international jury to earn the final grand prize, up to USD 500,000 in equity investment. Flitto, an innovative crowdsourcing translation platform from South Korea nabbed first place, with its CEO Simon Lee stating: “After Seedstars World came to Seoul, and crowned us Regional Winner, doors opened for us and we really gained traction. The publicity it created was also fantastic and this [global] win will take us even further.” – Advertisement – The quality of the startups of 2013’s 20 cities was impressive and participants, partners, and investors encouraged the team to explore other ecosystems as well, thus 10 new cities were added. More than 600 entrepreneurs from two thousand applications will be selected for the 30 pitching events in 2014.  The new round will also incorporate old friends, as former SSW regional winners continue to be part of the journey to help the company reach even more startups in their respective ecosystems.Alisee de Tonnac, CEO, stated that “Seedstars World will hold its worldwide competition every year and grow exponentially to all the corners of the world and put all the fast growing startup scenes on the map! Indeed, our goal is to create THE network for quality entrepreneurs around the world and help entrepreneurs, accelerators/incubators, co-working spaces and investors to interact with one another.”  The network aims to spread the Seedstars spark, which accelerated the regional winning startups’ progress by tripling their funding on average during the first edition in 2013. This currently amounts to a total of 6 million USD of follow-up funding.Making its debut in Uganda, Seedstars World is coming to Kampala for its twelfth event of the 2014 tour. This year, SSW will partner withthe Outbox, where the event will be hosted. The event is free to join and more information can be found on the Seedstars Kampala page.Competition Summary  30 regional events: an exclusive one-day event where the best-in-class startups pitch their ideas in front of a regional jury panel. Final event: the 30 finalists of the regional events will be invited to Switzerland to participate in a 4-day bootcamp and the grand finale where they will compete in front of an international jury and European investors. One winner will win up to USD 500’000 in equity investment.Criteria: –  less than USD 500’000 in capital investment – maximum 2 years since  founding date   – a product that is up and running on the market.  – a global project, potentially scalable at an international level. How to participate? Invitation only. If you are interested in receiving an invitation please contact us at  info@seedstarsworld.comlast_img read more

  • £25 FREE BET Chelmsford Racing

    first_img£25 FREE BET IFANY RACE AT CHELMSFORD WON BY A 16/1 OR MORE WINNERTo celebrate the launch of our brand new betting site starsports.bet we are giving all NEW CUSTOMERS a £25 FREE BET if ANY RACE AT CHELMSFORD IS WON BY A HORSE AT 16/1 OR MORE.You simply need to open an account and place a bet at evens or above, of at least £10, on any market at starsports.bet between 9am on Thursday 20 December and 5.30pm on Thursday 20 December. TERMS AND CONDITIONS(1) This promotion is for new account holders only. To qualify, you must open a new account at starsports.bet anytime from 9am on Thursday 20 December to 5.30pm (GMT) on Thursday 20 December.(2) In addition, you must place at least one bet online with starsports.bet before 5.30pm (GMT) on Thursday 20 December. The bet must be for a stake of £10 (or more), on a selection at evens or above, on any market as displayed on the starsports.bet web site.(3) The bonus promotional offer of £25 will be paid as a Free Bet if ANY RACE AT CHELMSFORD WON BY A HORSE AT 16/1 OR MORE (Chelmsford 8 races start 5.30pm). The Free Bet will be valid for a period of 7 days from the point of issue and must be used within this period otherwise will expire.(4) If, for any reason, the event(s) do not take place or are declared void for betting purposes this offer will also be voided.(5) The bonus Free Bet, if successful, will be credited within 48 hours, direct to your online account.(6) Free Bets may not be used in conjunction with any other current promotion.(7) Star Sports reserve the right to withdraw or refuse any Free Bet promotion at any point.(8) Free Bet stakes are not returned with winnings.(9) Free Bet awards cannot be exchanged for cash.(10) Free Bet awards can be used online, tablet or mobile only.(11) The Free Bet must be used within the timeframe specified on the promotion details and may not be either part used or carried forward.(12) This promotion can only be used once per person and per account. Only one bonus can be awarded per person, household, shared computer or shared IP address. In the event of a customer opening more that one account to claim multiple offers we reserve the right to suspend/close duplicate accounts and void any bets placed.(13) Usual Star Sports Betting Rules and Terms and Conditions apply, these can be viewed at starsports.bet.(14) If you have any further questions about this promotion you can contact our customer service team cs@www.starsportsbet.co.uklast_img read more

  • Openeducation pioneer wins Berkman Award for Internet innovation

    first_imgAddThis ShareCONTACT: Jade BoydPHONE: 713-348-6778E-MAIL: jadeboyd@rice.eduOpen-education pioneer wins Berkman Award for Internet innovationHarvard honors Connexions’ founder for impact of global education programHarvard Law School’s Berkman Center for Internet & Society has awarded Rice’s Richard Baraniuk with one of six inaugural Berkman Awards for founding the Connexions project, one of the world’s first open-education Web sites.The awards, which honor center namesake and communications law pioneer Jack Berkman, were announced at the center’s 10th anniversary gala May 16 in Boston. Recipients were chosen for outstanding contributions to the Internet’s impact on society over the past decade, and the winners represented nominees from diverse fields, including human rights and global advocacy, academia, communications and media, and law. Each winner received a $10,000 prize.Baraniuk, the Victor E. Cameron Professor in Electrical and Computer Engineering, founded Connexions in 1999. One of the web’s first Open Educational Resources (OER), Connexions is both a software platform and a repository that lets people create, share, modify and vet open educational materials that are accessible by anyone, anywhere, anytime for free. With content accessed by more than 850,000 visitors per month, Connexions is one of the world’s most popular OER sites.The complete list of Berkman Award winners is posted at  http://cyber.law.harvard.edu/node/4316.last_img read more

  • From eons to seconds proteins exploit the same forces

    first_imghttp://news.rice.edu/files/2014/08/0811_FUNNEL-2-web1.jpgA protein folding funnel, the product of algorithms created by Rice’s Center for Theoretical Biological Physics, is a graphic representation of the energy landscape a protein navigates as it goes from its initial floppy state to a folded, functional unit. The funnel shows smooth slopes as well as outcroppings where parts of a protein may pause while others catch up, and also traps that could cause a protein to misfold. New Rice research shows how the interplay between evolution and physics developed the skills necessary to conserve useful proteins. (Credit: Center for Theoretical Biological Physics/Rice University) http://news.rice.edu/files/2014/08/0811_FUNNEL-1-web.jpg http://news.rice.edu/files/2014/08/0811_FUNNEL-2-web.jpgRice University researchers have determined that the energy landscape involved in the long-term evolution of proteins is essentially the same as that involved in the folding process that takes as little as microseconds. Authors of the new work are, from left, Faruck Morcos, Ryan Cheng, Nicholas Schafer, Peter Wolynes and José Onuchic. (Credit: Tommy LaVergne/Rice University)Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,920 undergraduates and 2,567 graduate students, Rice’s undergraduate student-to-faculty ratio is just over 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is highly ranked for best quality of life by the Princeton Review and for best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go here. ShareEditor’s note: Links to images for download appear at the end of this release.David Ruth713-348-6327david@rice.eduMike Williams713-348-6728mikewilliams@rice.eduFrom eons to seconds, proteins exploit the same forcesRice University theorists show how energy landscapes dominate both evolution and folding of proteins HOUSTON – (Aug. 11, 2014) – Nature’s artistic and engineering skills are evident in proteins, life’s robust molecular machines. Scientists at Rice University have now employed their unique theories to show how the interplay between evolution and physics developed these skills.A Rice team led by biophysicists Peter Wolynes and José Onuchic used computer models to show that the energy landscapes that describe how nature selects viable protein sequences over evolutionary timescales employ essentially the same forces as those that allow proteins to fold in less than a second. For proteins, energy landscapes serve as maps that show the number of possible forms they may take as they fold.The researchers calculated and compared the folding of natural proteins from front to back (based on genomic sequences that form over eons) and back to front (based on the structures of proteins that form in microseconds). The results offer a look at how nature selects useful, stable proteins.In addition to showing how evolution works, their study aims to give scientists better ways to predict the structures of proteins, which is critical for understanding disease and for drug design.The research reported today in the Proceedings of the National Academy of Sciences shows that when both of the Rice team’s theoretical approaches — one evolutionary, the other physics-based — are applied to specific proteins, they lead to the same conclusions for what the researchers call the selection temperature that measures how much the energy landscape of proteins has guided evolution. In every case, the selection temperature is lower than the temperature at which proteins actually fold; this shows the importance of the landscape’s shape for evolution.The low selection temperature indicates that as functional proteins evolve, they are constrained to have “funnel-shaped” energy landscapes, the scientists wrote.Folding theories developed by Onuchic and Wolynes nearly two decades ago already suggested this connection between evolution and physics. Proteins that start as linear chains of amino acids programmed by genes fold into their three-dimensional native states in the blink of an eye because they have evolved to obey the principle of minimal frustration. According to this principle, the folding process is guided by interactions found in the final, stable form.Wolynes used this fundamental law to conceptualize folding in a new way. The top of his folding funnel represents all of the possible ways a protein can fold. As individual stages of the protein come together, the number of possibilities decreases and the funnel narrows and eventually reaches its functional native state.A funnel’s rugged landscape is different for every protein. It shows smooth slopes as well as outcroppings where parts of a protein may pause while others catch up, and also traps that could cause a protein to misfold.“The funnel shows that the protein tries things that are mostly positive rather than wasting time with dead ends,” Wolynes said. “That turns out to resolve what was called Levinthal’s paradox.” The paradox said even a relatively short protein of 100 acids, or residues, that tries to fold in every possible way would take longer than the age of the universe to complete the process.That may be true for random sequences, but clearly not for evolved proteins, or we wouldn’t be here. “A random sequence would go down a wrong path and have to undo it, go down another wrong path, and have to undo it,” said Wolynes, who in his original paper compared the process to a drunken golfer wandering aimlessly around a golf course. “There would be no overall guidance to the right solution.”So the funnel is a useful map of how functional proteins reach their destinations. “The only way to explain the funnel’s existence is to say that sequences are not random, but that they’re the result of evolution. The key idea of the energy landscape (depicted by the funnel) only makes sense in the light of evolution,” he said.While Onuchic and Wolynes have been advancing their theories for decades, only recently has it become possible to test their implications for evolution using two very different approaches they developed on the shoulders of their previous work.One of the algorithms they employ at Rice’s Center for Theoretical Biological Physics (CTBP) is called the Associative Memory, Water-Mediated, Structure and Energy Model (AWSEM). Researchers use AWSEM to reverse-engineer the folding of proteins whose structures have been captured by the century-old (but highly time-consuming) process of X-ray crystallography.The other model, direct coupling analysis (DCA), takes the opposite path. It begins with the genetic roots of a sequence to build a map of how the resulting protein folds. Only with recent advances in gene sequencing has a sufficiently large and growing library of such information become available to test evolution quantitatively.“Now we have enough data from both sides,” Wolynes said. “We can finally confirm that the folding physics we see in our structure models matches the funnels from the evolutionary models.”The researchers chose eight protein families for which they had both genomic information (more than 4,500 sequences each) and at least one structural example to implement their two-track analysis. They used DCA to create a single statistical model for each family of genomic sequences.The key is the selection temperature, which Onuchic explained is an abstract metric drawn from a protein’s actual folding (high) and glass transition (low) temperatures. “When proteins fold, they are searching a physical space, but when proteins evolve they move through a sequence space, where the search consists of changing the sequence of amino acids,” he said.“If the selection temperature is too high in the sequence space, the search will give every possible sequence. But most of those wouldn’t fold right. The low selection temperature tells us how important folding has been for evolution.”“If the selection temperature and the folding temperature were the same, it would tell us that proteins merely have to be thermodynamically stable,” Wolynes said. “But when the selection temperature is lower than the folding temperature, the landscape actually has to be funneled.”“If proteins evolved to search for funnel-like sequences, the signature of this evolution will be seen projected on the sequences that we observe,” Onuchic said. The close match between the sequence data and energetic structure analyses clearly show such a signature, he said, “and the importance of that is enormous.”“Basically, we now have two completely different sources of information, genomic and physical, that tell us how protein folding works,” he said. Knowing how evolution did it should make it much faster for people to design proteins “because we can make a change in sequence and test its effect on folding very quickly,” he said.“Even if you don’t fully solve a specific design problem, you can narrow it down to where experiments become much more practical,” Onuchic said.“Each of these methods has proved very useful and powerful when used in isolation, and we are just starting to learn what can be achieved when they are used together,” said Nicholas Schafer, a Rice postdoctoral researcher and co-author. “I’m excited to be participating in what I think will be an explosion of research and applications centered around these kinds of ideas and techniques.”Faruck Morcos is the paper’s lead author and Ryan Cheng is a co-author. Both are postdoctoral researchers at Rice. Onuchic is Rice’s Harry C. and Olga K. Wiess Professor of Physics and Astronomy and co-director of the CTBP based at Rice’s BioScience Research Collaborative. Wolynes is the Bullard-Welch Foundation Professor of Science and a professor of chemistry and a senior scientist with CTBP.The National Science Foundation, the National Institutes of Health, the CTBP, the Cancer Prevention and Research Institute of Texas and the D.R. Bullard-Welch Chair at Rice supported the research.The researchers utilized the Data Analysis and Visualization Cyberinfrastructure supercomputer supported by the NSF and administered by Rice’s Ken Kennedy Institute for Information Technology.-30-Read the abstract at http://www.pnas.org/content/early/2014/08/07/1413575111.abstractFollow Rice News and Media Relations via Twitter @RiceUNewsRelated Materials:José Onuchic: http://chemistry.rice.edu/FacultyDetail.aspx?p=51BE2F2C673C5991Wolynes Research Lab: http://wolynes.rice.edu/node/2?destination=node/2Center for Theoretical Biological Physics: http://ctbp.rice.eduBioScience Research Collaborative: http://brc.rice.edu/home/Images for download: AddThislast_img read more

  • Expert Alert Clean fossil fuels are no myth but a requirement

    first_imgShareEXPERT ALERTDavid Ruthdavid@rice.edu713-348-6327Clean fossil fuels are no myth, but a requirementHOUSTON – (Nov. 10, 2014) – A clear understanding of the facts drives the reality requiring global deployment of transformative technology for clean fossil fuels, according to Charles McConnell, executive director of Rice University’s Energy and Environment Initiative.In an opinion column in last week’s The Hill, McConnell said, “The concept of clean fossil technology is not a myth, and if we are serious as a society about our global environmental footprint, then we must confront reality and accept the challenge.”In the Hill column, “Clean fossil fuels are no myth, but a requirement,” McConnell explains that the world’s energy demand will double by 2050, with 90 percent of the growth coming from developing countries, and that fossil fuels will continue to provide 80 percent of the energy consumed through them.“Our global energy story must include transformative fossil fuel technology globally for a sustainable future over the next 50 to 100 years,” McConnell said. “If one really ‘cares’ about the environment, then accepting the challenge is the only option.”McConnell, who is also a former assistant secretary of energy at the Department of Energy (2011-2013), is available for news media interviews on the strategy and policies the United States must take moving forward.For more information or to schedule an interview with McConnell, contact David Ruth, director of national media relations at Rice, at 713-348-6327 or david@rice.edu.Rice University has a VideoLink ReadyCam TV interview studio. ReadyCam is capable of transmitting broadcast-quality standard-definition and high-definition video directly to all news media organizations around the world 24/7.-30-Follow Rice News and Media Relations via Twitter @RiceUNews. AddThislast_img read more

  • Core values inform Rices House

    first_img Rice University staff and students push the fourth wall of +House into place after inserting the core, which contains the bathroom, kitchen, heating and air conditioning and utility hookups. Return to article. Long Description Return to article. Long DescriptionRoque Sanchez puts some muscle into the core unit by pushing into the frame of +House, a Rice Construct project in Houston’s Third Ward.“We’ve done about 10 Saturdays of construction with people who are not very experienced at it,” said Danny Samuels, co-director of Rice Construct and a co-founder of Rice Building Workshop. “But it’s been going pretty quickly. I’m very proud of these students, because they’re self-starters.”On core day, after sweeping away the snow, graduate students Rose Wilkowski and Julie Klosterman, fifth-year student Shiori Sageshima and visiting student Leyla Hepsaydir spent a chilly morning closing in walls and pausing for the occasional Instagram photo while they awaited the core’s delivery from a storage facility across town.Once it arrived, and after a short time strategizing, the Rice staff and students winched and pushed it from the truck into position on the deck, after which they replaced the fourth wall’s frame and went back to work on the roof. They expected to have the building weatherproofed before Rice’s holiday break and will continue construction in January.Samuels said the team, which includes graduate students Kejia Lu and Haotian Ma, undergraduate John Rudd and fifth-year student Jiaxing Yan, hopes to complete the two-year project in the summer. At that time, two mentors now housed in the street-side building will move in, making room in the main house for more clients. Rice Architecture staff and students push and pull their core unit into position at the +House in Houston’s Third Ward. http://news.rice.edu/files/2017/12/1218_CORE-2-web-1yycfwx.jpgRice University staff and students push the fourth wall of +House into place after inserting the core, which contains the bathroom, kitchen, heating and air conditioning and utility hookups. (Credit: Rice University) Return to article. Long Description http://news.rice.edu/files/2017/12/1218_CORE-4-web-2ckt6vk.jpgRice Architecture students were greeted with a snow-covered frame in Houston’s Third Ward Dec. 8. The students are building +House, a two-bedroom home for Agape Development that features a core unit combining its bathroom, kitchen, heating, air conditioning and utility hookups. (Credit: Rice University)Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,879 undergraduates and 2,861 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for quality of life and for lots of race/class interaction and No. 2 for happiest students by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/RiceUniversityoverview. Return to article. Long DescriptionRice Architecture students were greeted with a snow-covered frame in Houston’s Third Ward Dec. 8. The students are building +House, a two-bedroom home for Agape Development that features a core unit combining its bathroom, kitchen, heating, air conditioning and utility hookups.Hepsaydir, at Rice on a yearlong fellowship after earning her architecture degree at Cambridge University, welcomed the chance to get hands-on experience. “In Cambridge, we never had any physical design-and-build, so this is a great opportunity to get my hands dirty,” she said. “And the fact that we have a real client makes it rewarding.”Roque Sanchez, manager of buildings and projects for Rice’s George R. Brown School of Engineering and a volunteer on the project, appreciated the opportunity to teach engineering principles to architecture students. “This is a real interesting cross-disciplinary project in getting architects to think about engineering from the get-go in designing buildings and to explore advanced building systems,” he said.“On most residential construction, the framing and carpentry go very quickly, but the plumbing and the electrical work take the longest and have the most expensive tradespeople,” Sanchez said. “It’s sort of backwards when you think about it. You wouldn’t go to the middle of a field or a driveway and build a car from scratch, but we do that with houses.”Samuels said the project aligns with a current conversation about urban density. “This is a national question,” he said. “Some cities encourage increasing density by building backyard houses. Some discourage it. Houston’s relatively neutral; they allow it but they don’t really encourage it.“So we’ve been looking at projects like this as a means of increasing urban density without changing the fabric of a neighborhood,” he said.-30-Follow Rice News and Media Relations via Twitter @RiceUNewsVideo: Roque Sanchez puts some muscle into the core unit by pushing into the frame of +House, a Rice Construct project in Houston’s Third Ward. https://youtu.be/iqoHtV0q1wcVideo produced by Brandon Martin/Rice UniversityRelated materials:Rice Construct: https://arch.rice.edu/facets/constructRice Architecture: https://arch.rice.eduRice Construct on Instagram: http://deskgram.org/rice.constructImages for download: FacebookTwitterPrintEmailAddThis Return to article. Long Description http://news.rice.edu/files/2017/12/1218_CORE-1-web-1wbk9qq.jpgRoque Sanchez puts some muscle into the core unit by pushing into the frame of +House, a Rice Construct project in Houston’s Third Ward. (Credit: Rice University) http://news.rice.edu/files/2017/12/1218_CORE-3-web-22ox0ph.jpgRice Architecture staff and students push and pull their core unit into position at the +House in Houston’s Third Ward. (Credit: Brandon Martin/Rice University) Return to article. Long Description Return to article. Long Description Roque Sanchez puts some muscle into the core unit by pushing into the frame of +House, a Rice Construct project in Houston’s Third Ward. Rice Architecture students were greeted with a snow-covered frame in Houston’s Third Ward Dec. 8. The students are building +House, a two-bedroom home for Agape Development that features a core unit combining its bathroom, kitchen, heating, air conditioning and utility hookups. video ShareNEWS RELEASEEditor’s note: Links to video and high-resolution images for download appear at the end of this release.David Ruth713-348-6327david@rice.eduMike Williams713-348-6728mikewilliams@rice.eduCore values inform Rice’s +HouseRice architecture students designing, building home for Third Ward nonprofitHOUSTON – (Dec. 18, 2017) – Four Rice University architecture students showed up at a construction site in Houston’s historic Third Ward early and ready to work Dec. 8. But first they had to clear the decks after a rare snowfall.It was already an unusual day in the city, but it was a big one for Rice Architecture students building a small two-bedroom home for Agape Development. The nonprofit program will use it to house counselors in an initiative that supports at-risk youth. A few hours later, the building’s “core” was delivered and put into place.The +House project in the backyard of an Agape home on Conley Street is the next iteration in the core concept being developed by Rice Construct, the new name for the 21-year-old operation known until recently as Rice Building Workshop.The core, a 3,000-pound box built on campus at Ryon Lab last summer, contains the bathroom, kitchen and electrical, heating and air conditioning systems in a single unit meant to slide into the building, simplifying construction and saving on-site costs. Once the core is in place, all the municipal utilities hook up at a central location.A previous iteration of the core, the Modpod, was inserted into a renovated home for Project Row Houses in 2012, but the 350-square-foot +House is the first core building that students have designed and built from scratch. After more than a year of planning and core construction, they have been building on-site since returning to school this fall. Rice Architecture students were greeted with a snow-covered frame in Houston’s Third Ward Dec. 8. The students are building +House, a two-bedroom home for Agape Development that features a core unit combining its bathroom, kitchen, heating, air conditioning and utility hookups. last_img read more

  • Baker Institute expert The embargo of Qatar will likely fail

    first_imgShareDavid Ruth713-348-6327david@rice.eduJeff Falk713-348-6775jfalk@rice.eduBaker Institute expert: The embargo of Qatar will likely failHOUSTON – (Jan. 25, 2018) – The decision by Bahrain, Egypt, Saudi Arabia and the United Arab Emirates (UAE) to embargo Qatar over its alleged support of terrorism was risky and without a clear endgame, according to a new issue brief by an expert in the Center for Energy Studies at Rice University’s Baker Institute for Public Policy.Qatar is a peninsula that borders the Persian Gulf and Saudi Arabia, in a strategic location near major oil and gas deposits. Credit: 123RF.com/Rice UniversityThe list of 13 demands presented in June 2017 by these anti-Qatar coalition countries suggests a supremely ambitious set of goals behind their embargo, including “red lines” that touch directly upon Qatari sovereignty and that leadership in the Qatari capital of Doha will almost certainly reject, said brief author Gabriel Collins, the Baker Botts Fellow in Energy and Environmental Regulatory Affairs. “The stage is thus set for a contest of endurance, one that with every passing month looks more likely to result in favor of Qatar,” he wrote.The brief, “Anti-Qatar Embargo Grinds Toward Strategic Failure,” provides evidence of the anti-Qatar blockade’s trajectory from initial shock to emerging strategic failure using actual market data. It also discusses potential paths forward and the economic and security ramifications of those options.“At this point, it is difficult to envision Qatar making unilateral concessions that could lead to the embargo being lifted,” Collins wrote. “The worst of the post-blockade capital flight is likely over, the country is rebuilding its trade links and food-supply chain to bypass imports previously obtained via Saudi Arabia and the UAE, and liquefied natural gas exports remain robust, underpinning Qatari cash flow. From this point, the embargo could remain in place for years and Qatar could very likely withstand the effects with decreasing impact each year as it increasingly emphasizes economic relationships outside the Gulf region.”Collins noted that Qatar is net self-sufficient in steel production (including rebar critical for construction as it prepares for the 2022 World Cup). Likewise, the new Hamad Port — capable of storing enough cereal grains to satisfy multiple years of local consumption, able to handle more than 3.5 million 40-foot shipping containers per year and able to accept 1.7 million metric tons per year in general cargo — is already replacing import trade that formerly came by land from Saudi Arabia and by sea from the UAE, he said.“As the embargo continues, diplomatic and political relationships between many Arab countries will likely suffer further damage, and Iran’s relative influence in the region will likely rise as a result,” Collins wrote. “The ultimate consequences of increased Iranian influence across the region remain debatable, but from the perspective of the countries embargoing Qatar, as well as that of the United States, this is clearly an unintended consequence.”Collins conducts a range of globally focused commodity market, energy, water and environmental research. His current research focuses on oilfield water issues, groundwater valuation in Texas, evolutions in the global gasoline market, shifts in China’s domestic oil consumption structure, Texas water governance and the food-water-energy nexus.-30-For more information or to schedule an interview with Collins, contact Jeff Falk, associate director of national media relations at Rice, at jfalk@rice.edu or 713-348-6775.Related materials:Issue brief: www.bakerinstitute.org/research/anti-qatar-embargo-grinds-toward-strategic-failure.Collins biography: www.bakerinstitute.org/experts/gabe-collins.Baker Institute’s Center for Energy Studies: www.bakerinstitute.org/center-for-energy-studies.Follow the Center for Energy Studies via Twitter @CES_Baker_Inst.Follow the Baker Institute via Twitter @BakerInstitute.Follow Rice News and Media Relations via Twitter @RiceUNews.Founded in 1993, Rice University’s Baker Institute ranks among the top five university-affiliated think tanks in the world. As a premier nonpartisan think tank, the institute conducts research on domestic and foreign policy issues with the goal of bridging the gap between the theory and practice of public policy. The institute’s strong track record of achievement reflects the work of its endowed fellows, Rice University faculty scholars and staff, coupled with its outreach to the Rice student body through fellow-taught classes — including a public policy course — and student leadership and internship programs. Learn more about the institute at www.bakerinstitute.org or on the institute’s blog, http://blogs.chron.com/bakerblog. AddThislast_img read more